Abstract: Taking the SCIE, SSCI and ESI papers co-published by China and 64 countries in the Belt and Road initiative area from 2008 to 2017 as the research data, this paper analyzed the research cooperation intensity, the depth of cooperation, cooperation scope and influence, respectively from the total number of cooperation papers, number of ESI cooperation, the number of cooperative papers accounting for the total number of articles published in the country, the first author and corresponding author countries, research institutes and research field, so as to provide reference for building cooperated mechanism between the national scientific research institutions and international scientific and technological organizations of China and countries in the Belt and Road initiative area. The results showed that the total number of papers and the number of ESI papers maintained growth trend and China played a growing important role in the ESI papers published by the Belt And Road countries. ESI papers which collaborated by China and more than two Belt And Road countries were less, developed countries, especially the USA played important role in cooperation. Collaborative ESI papers were distributed in the journal with high influence in all disciplines, and clinical trials and epidemiology, high-energy nuclear physics and particle physics, carbon nanocomposites, and network model design and algorithms are hot topics.