Abstract: This paper probed into the concept of digital humanism and its challenges and opportunities for library subject service, and summarized and analyzed the domestic and overseas practical activities of libraries participating in digital humanities. In the open sharing academic communication era, library should comply with the requirements of the times, enhance the understanding of digital humanities, reserve for the talent, technology and resource construction, so as to change the existing mode of discipline service from the passive response to the acquisition of more resource and space through participating in the digital humanities, and provide the ways for the expansion and extension of library service ability.