Abstract: Library space reconstitution is a breakthrough for the traditional library lending service model, and also an important way to promote communication between libraries and readers. This paper referred to the theory of digital humanities, and expounded the value of digital humanities to library space reconstitution, and analyzed the existing problems from the aspects of science and technology, reading environment and space function, and discussed the development strategies of space reconstitution based on digital humanities, so as to promote the sustained and healthy development of librarianship.